There is no evidence that the use of either continuous or intermittent therapies have a survival benefit in critical illness Continuous modalities have been Several benefits have been proposed from the use of continuous modalities: Improved haemodynamic stability and...
Intermittent Haemodialysis Continuous RRT Peritoneal Dialysis Advantages Efficient and intensive techniqueAllows for down-time for interventionsCan be performed overnightStaff required for a shorter timeLower costs Provides better haemodynamic stabilityEfficient...
Solutes to be Removed from the Plasma Patient`s Cardiovascular and Neurological Status Availability of Resources Clinician`s Experience Other Specific Clinical Considerations Hemofiltration is better at removing middle moleculesHemodialysis better at removing small...
Small Molecules Middle Molecules Protein-Bound Molecules Size <500 Da 500 - 60,000 Da Albumin is 66 kDa (Not a middle molecule!) Variable Examples UreaCreatininePotassiumOxalateUric acid InterleukinsCytokinesB2 -microglobulinANPTNFLight chains HomocysteineHippuric...
Haemodialysis Haemofiltration Haemodiafiltration (Combined) Mechanisms Clearance of solutes via diffusion down a concentration gradientA counter-current flow of a solution containing various electrolytes on the opposite side of membrane to blood allows diffusion to...
