Key PrinciplesAggressive respiratory and cardiovascular supportive careEarly anticoagulation with LMWH or UFHThrombolysis if evidence of haemodynamic instability or cardiac arrest Resuscitation & Supportive Care Airway and respiratory support:Apply 100% oxygen...
Elevated serum D-dimer levels are highly sensitive but have low specificity D-diner should only be used following assessment of clinical probability: Should not be performed in those with a high clinical probability of PE A negative D-dimer test can reliably exclude...
Degradation products of cross-linked fibrin: Released when plasmin, the main fibrinolytic enzyme, cleaves fibrin cell Results in fragments containing two linked D-domains of fibrinogen with or without a single E-domain Presence in blood indicates simultaneous...
Parameter Clinical signs of DVT (pain and swelling) Alternative diagnosis less likely Tachycardia (>100bpm) Immobile for 3 days or major surgery in the past 4 weeks Previous VTE Haemoptysis Active cancer (within 6 months) Score 3 3 1.5 1.5 1.5 1 1 Score ≤ 4...
