Incidence of major bleeding ~9% following thrombolysis: Most commonly occurs at sites of invasive procedures 3% risk of intracranial haemorrhage Bleeding also common from gastrointestinal tract or genitourinary...
Absolute History of intracranial hemorrhage, intracranial neoplasm, arteriovenous malformation, or aneurysmRecent (<2 months) intracranial surgery or traumaActive or recent internal bleeding Relative Known bleeding diathesis• Non-haemorrhagic stroke within the...
High-risk (massive) PE Selected cases of intermediate-risk (sub-massive) PE: Currently not routinely recommended by ESC guidance Some evidence it improves long term outcomes ESC Guidelines...
Anticoagulation should be initiated without delay, while diagnostic workup in progress, in patients with: Suspected PE with haemodynamic instability Suspected PE without haemodynamic instability with a high or intermediate clinical probability ESC Guidelines...
Acute Management Parenteral, weight-adjusted anticoagulation should be used:Low-molecular weight heparin (LMWH) SCFondaparinux SCUnfractionated heparin (UFH) IVGenerally second line due to higher bleeding risk and HIT riskPreferred agent in the setting of:Overt...
