Description The graph is a log dose-response curve with log drug dose on the x-axis and % of maximal effect on the y-axisA standard sigmoid curve represents a full agonist aloneA non-competitive antagonist prevents antagonist binding and the effect is...
Description The graph is a log dose-response curve with log drug dose on the x-axis and % of maximal effect on the y-axisA standard sigmoid curve represents a full agonist aloneAt low doses a competitive irreversible antagonist is surmountable at high concentrations...
Description The graph is a log dose-response curve with log drug dose on the x-axis and % of maximal effect on the y-axisA standard sigmoid curve represents a full agonist aloneA second curve to the right of the first curve can be drawn to show the effect of the...
Competitiveness Competitive Non-competitive Reversibility Reversible Irreversible Surmountability Surmountable Insurmountable The antagonist and agonist compete for the same binding siteReduces the number of free receptor sites for agonist binding The antagonist binds...
Describes disruption to the agonist effect occurring at cellular sites distinct from the receptor mediating the response Can include mechanisms such as: Indirect antagonism: competition for the binding site of an intermediate macromolecule that links the binding of...
