Description
- The graph is a log dose-response curve with log drug dose on the x-axis and % of maximal effect on the y-axis
- A standard sigmoid curve represents a full agonist alone
- At low doses a competitive irreversible antagonist is surmountable at high concentrations but at the expense of decreased potency of the agonist - represented by a curve to the right of the first curve
- At high doses the antagonistic effects become insurmountable despiute increasing agonist concentrations - represented by a curve to the right represeting reduced potency, and with a lower height representing reduced maximal effect