In the absence of emergency indications: Current evidence does not firmly confirm advantages of either an early or late initiation of RRT Most evidence supports the use of a “wait and see” attitude without leading to worse outcomes Patient should be considered as a...
RCT: ELAINZarbock et alJAMA (2016)View Paper RCT: AKIKIGaudry et alNEJM (2016)View Paper RCT: IDEAL-ICUBarbar et alNEJM (2018)View Paper Intervention Early vs. Late initiation of RRTEarly: Within 8 hours of meeting KDIGO stage 2 AKILate: Within 12 hours of meeting...
Early Initiation Late Initiation May confer benefit, in particular in circumstances in which there is a perception that recovery from AKI is not imminentCan theoretically facilitate more rapid correction of electrolyte and acid-base derangements and control of uraemia...
Low volume of distribution Low molecular weight Low protein binding Low water solubility Memory Tip Can be remembered using the mnemonic: I STUMBLE Isopropyl Salicylates Theophylline Urea Methanol Barbiturates and anti-convulsants: Phenobarbital Carbamazepine...
