RCT: ELAINZarbock et alJAMA (2016)View Paper RCT: AKIKIGaudry et alNEJM (2016)View Paper RCT: IDEAL-ICUBarbar et alNEJM (2018)View Paper Intervention Early vs. Late initiation of RRTEarly: Within 8 hours of meeting KDIGO stage 2 AKILate: Within 12 hours of meeting...
Adequate clearance, and how this influences outcome is not clear: Current research suggests that a rate of 20-25ml/kg is adequate Higher rates of clearance (35-40ml/kg) confer no benefit Higher rates may need to be prescribed to ensure minimum desired clearance is met...
Blood Flow Rate Dialysate or Replacement Fluid Composition Replacement Fluid Pre/Post Dilution Ratio Effluent Rate (Dose) Fluid Removal Goal Anticoagulation Choice Blood flow rates are typically slower than in intermittent dialysis (150-200mL/min)Generally, the faster...
Guidance suggests RRT can be stopped when it is no longer required due to: Intrinsic recovery of kidney function Treatment no longer consistent with goals of care (withdrawal) However, determining when intrinsic function is adequate is difficult and no clear consensus...
KDIGOView Guideline NICEView Guideline Recommendation Initiate RRT emergently when life-threatening changes in fluid, electrolyte, and acid-base balance existConsider the broader clinical context, the presence of conditions that can be modified with RRT, and trends of...
