• Adequate clearance, and how this influences outcome is not clear:
    • Current research suggests that a rate of 20-25ml/kg is adequate
    • Higher rates of clearance (35-40ml/kg) confer no benefit
    • Higher rates may need to be prescribed to ensure minimum desired clearance is met
  • High volume hemofiltration may be of benefit in:
    • Rhabdomyolysis
    • Clearance of ammonia and lactate
    • Pancreatitis (experimental)
    • Clearance of cytokines (experimental)
Optimum 'dose' range of continuous renal replacement therapy