- Adequate clearance, and how this influences outcome is not clear:
-
- Current research suggests that a rate of 20-25ml/kg is adequate
- Higher rates of clearance (35-40ml/kg) confer no benefit
- Higher rates may need to be prescribed to ensure minimum desired clearance is met
- High volume hemofiltration may be of benefit in:
- Rhabdomyolysis
- Clearance of ammonia and lactate
- Pancreatitis (experimental)
- Clearance of cytokines (experimental)
