Structure & Chemical Properties Molecular StructureImidazoline derivativeChemical name is 2-((2,6-dichlorophenyl) amino)-2-imidazoline hydrochlorideChemical formula is C9H9Cl2N3 Chemical PropertiesBasic molecule with pKa 8.06Highly lipophilic due to dichlorophenyl...
Effect Timings Onset of Effect <5 minutes following loading & infusion) Peak of Effect Within 15 minutes following loading & infusion Duration of Effect Given as infusion Context Sensitive Half Time Favourably short, up to 4 hours after prolonged infusion...
Effect Timings Onset of Effect IV: 5-7 minutesPO: 1-2 hours Duration of Effect IV: 3-7 hoursPO: Up to 8 hours Absorption 70-100% Oral Bioavailability Absorption is rapid, with peak plasma levels within 1-2 hours Comments Distribution Distribution 20% Protein Binding...
Mechanism of Action Selective agonist at presynaptic alpha-2 adrenoceptors:More selective than clonidine with ratio of alpha-1:alpha-2 1:1,620More pronounced effect on central alpha-2 receptorsActs particularly on the locus coeruleus in the floor of the fourth...
Mechanism of Action Selective agonist at presynaptic alpha-2 adrenoceptors:Less selective than dexmedetomidine with ratio of alpha-1:alpha-2 1:200Acts particularly on the locus coeruleus in the floor of the fourth ventricle, producing depression of thalamic...
