Clonidine and dexmedetomidine are not pure alpha-2 adrenoceptor agonists, but also act at several different receptors Specific drug effects depend on the relative selectivity for each receptor type: Receptor Location Effect Alpha-2 Widespread throughout the brain and...
Several alpha-2 agonists are available: Clonidine Dexmedetomidine Medetomidine Tizanidine Guanfacine Of these, only clonidine and dexmedetomidine are regularly used in the...
Belong to a family of membrane-bound guanine nucleotide-binding protein-coupled receptors Consists of three main subtypes with different actions: Receptor Location Effect Alpha-2A Prefrontal cortex and locus coeruleus of the brain Suppresses neuronal firing reducing...
Structure & Chemical Properties Molecular StructureImidazoline derivativeDextroisomer of the veterinary sedative medetomidineChemical name is (S)-4-[1-(2,3-Dimethylphenyl)ethyl]-3H-imidazole Chemical formula is C13H16N2 Chemical PropertiesBasic molecule with pKa...