Which receptors do clonidine and dexmedetomidine act on?

Clonidine and dexmedetomidine are not pure alpha-2 adrenoceptor agonists, but also act at several different receptors Specific drug effects depend on the relative selectivity for each receptor type: Receptor Location Effect Alpha-2 Widespread throughout the brain and...

What are the alpha-2 receptors, and what are their functions?

Belong to a family of membrane-bound guanine nucleotide-binding protein-coupled receptors Consists of three main subtypes with different actions: Receptor Location Effect Alpha-2A Prefrontal cortex and locus coeruleus of the brain Suppresses neuronal firing reducing...

Describe the physico-chemical properties of dexmedetomidine?

Structure & Chemical Properties Molecular StructureImidazoline derivativeDextroisomer of the veterinary sedative medetomidineChemical name is (S)-4-[1-(2,3-Dimethylphenyl)ethyl]-3H-imidazole Chemical formula is C13H16N2 Chemical PropertiesBasic molecule with pKa...