Stage 1Exudative0-7 days 2Proliferative7-14 days 3Fibrotic>14 days Histopathology Acute inflammatory reaction in the lung caused by insult to the epitheliumAlveoli fill with neutrophils, blood and a protein-rich pulmonary oedemaAssociated alveolar epithelial and...
Traditionally considered as pulmonary and extra-pulmonary causes Ongoing debate about whether the 2 represent different disease processes Practically, treated in the same way Pulmonary (Direct insult to the lungs) PneumoniaAspirationSmoke inhalationPulmonary...
Mortality rates vary substantially according to trials: Reported range 23-72% Range in RCTs 25-30%· Mortality rate of ARDS has progressively declined over the last decade Prognosis is dependent on severity of disease: Mild Moderate Severe Mortality (%) 27 32 45 Sepsis...
The reported incidence of ARDS is highly variable: 2.5%–19% in studies of ICU patients 8.1% in a sole study in UK ICU The most extensive study looking at the epidemiology of ARDS is the LUNG SAFE trial: Observational study across 50 ICUs in 5 continents A total of...
The Berlin Criteria classifies ARDS severity based upon the P/F ratio when on a PEEP of 5 Mild Moderate Severe P/F Ratio (mmHg / kPa) 201 - 300 mmHg (≤ 39.9 kPa) 101 - 200 mmHg (≤ 26.6 kPa) ≤ 100 mmHg (≤ 13.3...
