1 Location Starts in the proximal tubules, but continues up to the distal tubules Process Hydrogen ions are secreted into the tubular lumen in exchange for Na+ ionsLeads to the conversion of Na2HPO4 (basic phosphate) to NaH2PO4 (acid phosphate) - the phosphate buffer...
1 Location Around 80% reabsorbed in the proximal convoluted tubule (PCT)Remaining HCO3- reabsorbed in the distal convoluted tubule and collecting ducts Process CO2 combines with water to form carbonic acid, catalysed by carbonic anhydraseThe H2CO3 then ionizes to H+...
1 Location Primarily proximal convoluted tubules Process CO2 combines with water to form carbonic acid, catalysed by carbonic anhydraseH2CO3 dissociates to form to H+ and bicarbonateH+ ions are secreted into the tubular lumen in exchange for Na+ Na+ ions and HCO3- are...
An important function of the kidney is to regulate the pH of the extracellular fluid Excretion of H+ ions with generation of HCO3- Buffering of H+ to promote excretion: Phosphate buffer systemAmmoniagenesis and ammonia buffer systemReabsorption of filtered bicarbonate...
The histidine side chain of Haemoglobin is able to bind an H+ ion Has a pKa of 6.8 and forms an important buffer system in the blood Deoxyhaemoglobin is better able to bind H+ than oxyhaemoglobin (contributes to Haldane...
