2.2.1 Laboratory Investigations Archives - Page 2 of 4

What are the causes of raised CSF white cell count (pleocytosis)?

Infectious conditions Viral meningoencephalitisBacterial meningoencephalitisTB meningitisFungal meningitisNeurosyphilisLyme diseaseParasitic infectionsV-P shunt infection Inflammatory conditions Cerebral vasculitisDemyelinating disease Vascular conditions Subarachnoid...

What is the normal white cell count in CSF? How can you correct for blood contamination of CSF when determining the white cell count?

Normal CSF may contain up to 5 WBCs per mm3 in adults Blood contaminating CSF in the setting of haemorrhage or traumatic tap can disrupting the white cell count The ratio of WBC to RBC in blood is roughly 1:750 It is suggested to correct the white cell count by...

What is a normal red cell count in CSF? What are the causes of red cells in the CSF?

Normally, there are no RBCs in the cerebrospinal fluid Traumatic lumbar tap: Occurs in 20% of lumbar punctures Differentiated from haemorrhagic causes by a falling RBC count across three bottles counted in order of collection Subarachnoid haemorrhage Intracerebral...

What are the causes of elevated CSF protein?

Infective conditions Inflammatory conditions Vascular conditions Endocrine conditions Medications / toxins Other Bacterial infectionsTuberculous infectionsFungal infectionsCerebral abscess Guillian-Barre SyndromeMultiple sclerosis Subarachnoid haemorrhageCerebral...

What is a normal CSF protein level?

Normal range in an adult is 0.2 – 0.4 g/L May be falsely elevated following a traumatic tap: Can be corrected by subtracting 10mg/L for every 1000 RBCs/mm3 Correction is only accurate if the same tube is used for the protein and cell...

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