Which structures make up the blood-brain barrier? Comprises of 3 cellular layers and a basement membrane Together these form a barrier virtually impenetrable barrier to lipophobic molecules Capillary Endothelium Basement Memebrane Pericytes Astrocytes Interconnected...
How do substances cross the blood-brain barrier and which substances pass by each route? Route Free Membrane Diffusion Membrane Channels Carrier-Mediated Transport Receptor-Mediated Transport (via transcytosis) Adsorption mediated transport (via transcytosis) Examples...
How does the makeup of CSF compare with plasma? Despite their common origin, CSF and plasma have a number of important differences: Na+, Cl- and Mg2+concentrations are higher K+ and Ca2+ concentrations are lower than plasma Protein is <1% of plasma resulting in...
What is the normal volume of cerebrospinal fluid (CSF)? Overall volume is between 100-150ml 2⁄3 within the ventricles 1⁄3 within the subarachnoid space around the spinal cord (35ml) Equates to ~10% of intracranial volume What is the pressure of cerebrospinal fluid...
What is the normal volume of cerebrospinal fluid (CSF)? Overall volume is between 100-150ml 2⁄3 within the ventricles 1⁄3 within the subarachnoid space around the spinal cord (35ml) Equates to ~10% of intracranial volume What is the pressure of cerebrospinal fluid...
