Which structures make up the blood-brain barrier? Comprises of 3 cellular layers and a basement membrane Together these form a barrier virtually impenetrable barrier to lipophobic molecules Capillary Endothelium Basement Memebrane Pericytes Astrocytes Interconnected...
Fundamentals What is cerebrospinal fluid (CSF)? Specialized transcellular fluid that surrounds the brain and spinal cord Circulates within the cerebral ventricular system and the subarachnoid space What is the normal volume of cerebrospinal fluid (CSF)? Overall volume...
What is the normal volume of cerebrospinal fluid (CSF)? Overall volume is between 100-150ml 2⁄3 within the ventricles 1⁄3 within the subarachnoid space around the spinal cord (35ml) Equates to ~10% of intracranial volume What is the pressure of cerebrospinal fluid...
How do substances cross the blood-brain barrier and which substances pass by each route? Route Free Membrane Diffusion Membrane Channels Carrier-Mediated Transport Receptor-Mediated Transport (via transcytosis) Adsorption mediated transport (via transcytosis) Examples...
How does the makeup of CSF compare with plasma? Despite their common origin, CSF and plasma have a number of important differences: Na+, Cl- and Mg2+concentrations are higher K+ and Ca2+ concentrations are lower than plasma Protein is <1% of plasma resulting in...