You should be able to:

  • Describe the epidemiology and prognosis of TTP and factors associated with a worse outcome
  • Explain the pathophysiological mechanisms underlying TTP
  • State the common causes of primary and secondary TTP
  • Explain the common tests used to diagnose TTP and the investigations used in the disease work-up
  • Describe the management of TTP including the role of PLEX, immunosuppression and specialist ICU care