You should be able to:
- Explain the common aetiologies of HLH (primary and secondary)
- Summarise the clinical features of HLH and when to suspect it in critically ill patients
- Describe the clinical scores and laboratory tests that are useful in diagnosing HLH
- Explain the pathophysiological mechanisms that can underlie HLH
- Summarise the key management principles in treating HLH and drugs that are commonly used
The Guidewire
Guidelines
Review Articles
- Astigarraga et al, An Pediatr (2018); Haemophagocytic syndromes: the importance of early diagnosis and treatment
- Schram et al, Blood (2015); How I treat hemophagocytic lymphohistiocytosis in the adult patient
- Brisse et al, Cytokine & Growth Reviews (2014); Hemophagocytic lymphohistiocytosis (HLH): A heterogeneous spectrum of cytokine-driven immune disorders
- George, J Blood Med (2014); Hemophagocytic lymphohistiocytosis: review of etiologies and management Usmani et al, BJH (2013); Advances in understanding the pathogenesis of HLH