Effect Timings Onset of Effect IV: 5-7 minutesPO: 1-2 hours Duration of Effect IV: 3-7 hoursPO: Up to 8 hours Absorption 70-100% Oral Bioavailability Absorption is rapid, with peak plasma levels within 1-2 hours Comments Distribution Distribution 20% Protein Binding...
Systemic Effects CNS Sedation and anxiolysis:Effects comparable to normal sleepMay be more co-operative and communicative than patients sedated with other drugsDecreases cerebral blood flow, but does not lower intracranial pressureDecreases intraocular pressure AS...
No definitive contraindicationsExtreme caution should be exercised in patients with:Heart blockBradycardiaHypotension or hypovolaemiaSevere ventricular dysfunction Peripheral vascular diseaseConcomitant use of:Beta-blockers (bradycardia)Tricyclic antidepressants...
