Sedation on critical careSedation of intubated and mechanically ventilated patients as an adjunct to other sedativesTreatment of agitated and delirious patientsMust be weaned gradually IV infusion: 0.5-1.0 mcg/kg/hrIV/PO: 50-200 mcg QDS Adjunct to anaesthesiaReduces...
Selective agonist at presynaptic alpha-2 adrenoceptors:Less selective than dexmedetomidine with ratio of alpha-1:alpha-2 1:200Acts particularly on the locus coeruleus in the floor of the fourth ventricle, producing depression of thalamic transmission to the cerebral...
Several alpha-2 agonists are available: Clonidine Dexmedetomidine Medetomidine Tizanidine Guanfacine Of these, only clonidine and dexmedetomidine are regularly used in the...
Structure & Chemical Properties Molecular StructureImidazoline derivativeChemical name is 2-((2,6-dichlorophenyl) amino)-2-imidazoline hydrochlorideChemical formula is C9H9Cl2N3 Chemical PropertiesBasic molecule with pKa 8.06Highly lipophilic due to dichlorophenyl...
