You should be able to:
• Describe the normal ICP pressure and waveform
• Explain which factors affect ICP and the relationship between intracranial pressure and volume
• Describe normal cerebral blood flow and oxygen requirements
• Explain cerebral perfusion pressure and the factors determining it
• Describe the concept of autoregulation
• Draw and explain a graph demonstrating cerebral autoregulation
Explain the factors that affect cerebral blood flow including oxygen, carbon dioxide, metabolic mediators and commonly used drugs
The Guidewire
Review Articles
- Tameem et al, BJA Ed (2013); Cerebral Physiology
- Das et al, Anaes Int Care (2019); Applied cerebral physiology
- Sakka et al, Eur Ann Otorhinolaryngology (2011); Anatomy and physiology of cerebrospinal fluid
- Shatzmiller et al, J Neur Dis & Stroke (2016); Blood-Brain Barrier Crossing for Therapeutic and Diagnostic Agents