Drug Factors
- Protein binding:
- Highly protein bound drugs (e.g. warfarin, diazepam, propranolol and phenytoin) are only cleared by RRT in small amounts
- Molecular weight:
- Larger molecules cleared less effectively by diffusive therapies
Therapy Factors
- Timing of RRT:
- Drugs given between sessions will not be cleared until the subsequent session
- Dose of RRT:
- Reduced flow rates / shorter sessions will decrease clearance of drugs
- Membrane permeability
Patient Factors
- Residual GFR and urine production
- Hypoalbuminaemia