Affecting Cerebral Perfusion Pressure
  • Changes in mean arterial pressure (MAP)
  • Changes in intracranial pressure (ICP)
  • Changes in central venous pressure (CVP)
Affecting Radius of Cerebral Vessels
  • Myogenic control
  • Metabolic mediators:
    • pCO2
    • pO2
    • Cerebral metabolic rate
    • Temperature
  • Neurogenic mediators
  • Endothelial mediators
  • Chemical mediators:
    • Volatile anaesthetics
    • Intravenous anaesthetics
Affecting Blood Rheology
  • Haematocrit