What is the mechanism of action of SSRIs?

  • Serotonin reuptake inhibition (leads to increased 5HT in the synaptic cleft):
    • 5HT1A agonism – Antidepressant, anxiolytic, anti-obsessive, antibulimic effects
    • 5HT2 agonism – Agitation, Akathisia, anxiety/panic, insomnia, sexual dysfunction;
    • 5HT3 agonism – Nausea, GI upset