What is the evidence for a conservative fluid status in ARDS?

Intervention
Population
Conclusion

RCT

ARDSNet
NEJM (2006)

View Paper

  • Conservative vs. liberal fluid strategy for 7 days
  • FB after 7 days was 136±491 ml in the conservative-strategy group and 6992±502 ml in the liberal-strategy group
  • 1,000 patients with ARDS
  • No significant difference in 60-day mortality (conservative 25.5% vs. liberal 28.4%, p=0.30)
  • Conservative fluid group showed:
    • Improved oxygenation index
    • Increased number of ventilator-free
    • No increase in the prevalence of shock or AKI requiring RRT)
    The Bottom Line Review