Febrile illness (prolonged) associated with multiple organ involvement:
- Reticuloendothelial manifestations:
- Hepatosplenomegaly (95%)
- Lymphadenopathy (33%)
- CNS dysfunction (35%):
- Seizures
- Cranial nerve palsy
- Altered sensorium
- Respiratory dysfunction:
- Respiratory failure
- Alveolar / interstitial infiltrates
- Cutaneous manifestations (up to 65%)
- Maculopapular erythematous rashes
- Generalised erythroderma
- Oedema
- Panniculitis
- High serum ferritin (>500, usually higher)
- Haematological abnormalities:
- Thrombocytopenia
- Anaemia
- Coagulopathy
- Hypofibrinogenemia
- Deranged LFTs:
- Hyperbilirubinaemia
- Transaminitis
- Hypertriglyceridemia