Absolute
- History of intracranial hemorrhage, intracranial neoplasm, arteriovenous malformation, or aneurysm
- Recent (<2 months) intracranial surgery or trauma
- Active or recent internal bleeding
Relative
- Known bleeding diathesis• Non-haemorrhagic stroke within the prior 2 months
- Surgery within the previous 10 days
- Thrombocytopaenia (platelets <100x109/l
- Uncontrolled severe hypertension (systolic BP >200mmHg or diastolic >110mmHg)