How should fluid replacement be managed for patients with SJS/TEN?

  • Traditionally patients have been managed as burns patients:
    • Parkland formula applied for involvement >15%
    • Can result in overaggressive fluid replacement and related complications
  • Alternative regime of 2 mL/kg/ body weight / % BSA epidermal detachment / 24 hours has been suggested
  • Should be guided by urine output, lactate and other markers of tissue perfusion

Shiga et al.

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