- Can be difficult as share similar clinical and pathophysiological features
- Differentiating clinical features include:
- ↑ presence of focal neurological symptoms in TTP
- ↑ presence of renal failure in HUS
- Typical HUS:
- Associated with exposure to shiga toxin – may be preceded by history of bloody diarrhoea
- Commonly presents in children <5
- Is associated with a higher platelet count than TTP (usually >35 x 109/L