• Can be difficult as share similar clinical and pathophysiological features
  • Differentiating clinical features include:
    • ↑ presence of focal neurological symptoms in TTP
    • ↑ presence of renal failure in HUS
  • Typical HUS:
    • Associated with exposure to shiga toxin – may be preceded by history of bloody diarrhoea
    • Commonly presents in children <5
    • Is associated with a higher platelet count than TTP (usually >35 x 109/L