Describe the pharmacodynamics of thionamide drugs?

Mechanism of Action Inhibits thyroid hormone production via inhibition of thyroid peroxidase. Blocks iodide oxidation and organification Propylthiouracil also lowers peripheral conversion of T4 to T3 by inhibiting 5′-deiodinase.   Toxicity & Side...

How are thyroid hormones regulated?

Thyroid hormone production is regulated by a series of negative feedback loops Thyroid stimulating hormone (TSH) is an important regulator: Peptide hormone produced in the anterior pituitary gland Stimulates the production and release of thyroid hormones TSH...