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What are the methods used to optimise the haematological system of the potential organ donor? Which physiological values should be targeted?

Classification of PE severity has traditionally been based on haemodynamic stability: Massive Sub-Massive Mild / Non-Massive Cardiovascular compromise with a systolic blood pressure (SBP) <90 mmHg or a drop in systolic pressure of >40 mmHg No systemic...

What are the methods used to optimise the respiratory system of the potential organ donor? Which physiological values should be targeted?

System Respiratory System Methods for Optimisation Lung recruitment maneuvers and PEEP following apnoea test Continue VAP prevention measures:30-45 degrees head up tiltTight endotracheal cuffPatient positioning as per unit protocolReview ventilation, ensure lung...

What are the methods used to optimise the cardiovascular system of the potential organ donor? Which physiological values should be targeted?

System Cardiovascular System Methods for Optimisation Use invasive haemodynamic monitoring: CVC should be inserted in right IJV or SCV Arterial line in Left radial or brachial artery due to order vessels are ligated Cardiac output monitoring to guide fluids and...

What are the pathophysiological changes affecting the haematological system that occur after brain death?

Coagulation Hemostatic disorders due to:Release of tissue thromboplastin by ischaemic or necrotic brainCatecholamine induced platelet dysfunction can occurDisseminated intravascular coagulation...

What are the pathophysiological changes affecting the metabolic / endocrine system that occur after brain death?

Endocrine & Metabolic System Failure of hypothalamic-pituitary axis due to ischaemia with:Impairment of temperature regulationADH depletion:Diabetes insipidus (DI) which occurs in up to 65% of organ donorsCharacterised by diuresis, hypovolaemia, plasma...
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