Barrier Functions Protects against potentially harmful molecules from entering the brainProvided through 4 main mechanisms:Paracellular barrier: endothelial tight junction restrict free movement of waterTranscellular barrier: Low level of inherent endocytosis and...
Certain areas of the brain have a reduced blood-brain barrier and retain a direct connection with the systemic circulation in order to Detect alterations in composition of the blood Allow secretion of hormones Areas that are outside the BBB are known as...
Comprises of 3 cellular layers and a basement membrane Together these form a barrier virtually impenetrable barrier to lipophobic molecules Capillary Endothelium Basement Memebrane Pericytes Astrocytes Interconnected by tight junctions (50-100x 'tighter' than...
Cerebrospinal fluid (CSF) is produced by the choroid plexuses of the lateral, third and fourth ventricles Passes from the lateral ventricles to the third ventricle through the two interventricular foramina (foramen of Monro) passes from the third ventricle to the...
Despite their common origin, CSF and plasma have a number of important differences: Na+, Cl- and Mg2+concentrations are higher K+ and Ca2+ concentrations are lower than plasma Protein is <1% of plasma resulting in reduced buffering capability and a lower pH Despite...
