FICM / ICSView Guideline ATS / ESICMView Guideline Recommendation Recommended for use in “selected” patients with severe ARDS (weak recommendation) Unable to make a definitive recommendation other than for further...
RCT: CESARPeek et alBMC Health Serv Res (2006)View Paper RCT: EOLIACombes et al NEJM (2018)View Paper Intervention Management in tertiary respiratory centre (75% receiving ECMO) vs. conventional ventilation in a referral centre Early initiation of ECMO vs....
FICM / ICSView Guideline Recommendation Recommendation against the use of iNO in patients with ARDS due to the lack of mortality benefit and suggestion of increased renal dysfunction (Weak...
Most of the trials have been performed using inhaled nitric oxide Overall there is no improvement in mortality Transient improvement in oxygenation which may make it useful as a bridge to other therapy RCTDellinger et al Crit Care Med (1988)View Paper RCTTaylor et...
Further information available here Drug Inhaled Nitric Oxide (iNO) Nebulised Prostacyclin Nebulised Milrinone Mechanism Activates soluble guanyl cyclase n smooth muscle leading to the conversion of GTP to cGMP resulting in vasodilatation Activates adenyl cyclase in...
