What causes low CSF glucose levels?

Can be due to caused due to Utilisation by pathogenic organisms Utilisation by host cells Impaired CSF glucose transport through the blood-brain barrier Conditions where low CSF glucose arises include: Infective conditions Bacterial infections: low...

What is xanthochromia?

Xanthochromia is a yellow, orange, or pink discoloration of the CSF Due to the breakdown products of haemoglobin (bilirubin) following lysis of red cells Begins after RBCs have been in CSF for about two hours and can remain for up to 2-4 weeks Ultraviolet light can...

Which conditions can cause abnormal visual appearance of CSF?

Appearance Clear Turbid Yellow / Orange / Pink Green Brown Cause Normal appearance Raised WBC count (>200/mm3)Raised RBC count (>400/mm3) Xanthochromia: subarachnoid haemorrhage, artifactual red cell lysis HyperbilirubinemiaHigh carotenoids ingestionRifampicin...

Which investigations can be performed on CSF?

Routinely Performed Opening pressureTotal Cell count (WBC & RBC)Cell differential countGlucose (CSF/plasma ratio)Total protein Useful in Specific Situations Microbiological stains:Gram stainAcid-Fast stainMicrobiological cultures:Bacterial cultureFungal cultureTB...