- Explain the functions of CSF
- Describe the normal CSF volume and pressure
- Outline the process of CSF production, circulation and reabsorption
- Compare the constituents of CSF and plasma and explain the key differences
- Describe the microscopic and macroscopic structure of the blood-brain barrier and state the key areas of the brain that lie outside
- Outline the functions of the blood-brain barrier
- Explain mechanisms of transfer of drugs and other molecules across the blood-brain barrier and how transport can be enhanced
The Guidewire
Review Articles
- Tameem et al, BJA Ed (2013); Cerebral Physiology
- Das et al, Anaes Int Care (2019); Applied cerebral physiology
- Sakka et al, Eur Ann Otorhinolaryngology (2011); Anatomy and physiology of cerebrospinal fluid
- Shatzmiller et al, J Neur Dis & Stroke (2016); Blood-Brain Barrier Crossing for Therapeutic and Diagnostic Agents