Description
- The graph is a log dose-response curve with log drug dose on the x-axis and % of maximal effect on the y-axis
- A standard sigmoid curve represents a full agonist alone
- A non-competitive antagonist prevents antagonist binding and the effect is insurmountable
- This results in decreased potency and decreased maximal effect of the agonist - the curve is shifted down and to the right
- The curve is similar in shape to the effects of a partial agonist alone