- Drug-receptor interaction is explained by the ‘law of mass action’:
- Proposes that the rate of binding is directly proportional to the product of the concentrations of the reactants
- Can be demonstrated by the equation:
[D] + [R] \underset{K_{on}}{\stackrel{K_{off}}{\rightleftharpoons}} [DR]
[D] is drug
[R] is receptor
[D-R] is drug–receptor complex
Kon is rate of forward reaction (assocation rate constant)
Koff is rate of backward reaction (dissociation rate constant)
[R] is receptor
[D-R] is drug–receptor complex
Kon is rate of forward reaction (assocation rate constant)
Koff is rate of backward reaction (dissociation rate constant)