Hormone
Hormone
Hormone
Parathyroid Hormone
- Protein hormone produced by chief cells of the parathyroid gland
- Secretion stimulated by a decrease in serum calcium levels
- Normal levels are 1.3 – 6.8 pmol/L
- Acts to increase serum calcium and decrease serum phosphate levels through a number of mechanisms:
- Kidney: Increases calcium reabsorption
- Bone: Mobilises calcium from bone stores by stimulating osteoclast activity and inhibiting osteoblast activity
- GI Tract: Increases GI absorption of calcium and phosphate indirectly by production active vitamin D metabolites