Severe disease is complicated by organ failure:

Neurological
  • Seizures
  • Paralysis
  • Ischaemic Changes
  • Cerebral Bleeding
  • Coma
Renal
  • Renal Failure
Cardiovascular
  • Acute myocardial infarction
  • Arrhythmias
  • Heart failure
  • Cardiogenic shock
Other organs
  • Pancreatitis
  • GI Bleeding
  • Mesenteric Ischaemia