- Small volume of distribution (<1L/kg) 1
- Low degree of protein-binding 1
- High water solubility 1
- Low molecular weight 1:
- Only smaller molecules (up to 500 Da) are cleared by hemodialysis
- Up to a maximum 40 kDa can be cleared by hemofiltration
- Low endogenous clearance (<4 ml/min/kg) 1
- Extraction ratio exceeding endogenous elimination 1
