How can you prevent ICU patients from developing PRIS?

  • Use propofol with caution for long-term sedation in critically ill patients
    • For long-term sedation, propofol dose should not exceed 4 mg/kg/h
  • Frequent monitoring:
    • Arterial blood gases,
    • Serum lactate,
    • CK
    • Triglycerides
  • Providing adequate carbohydrate intake
  • Minimize lipid loads (e.g. from lipid-based parenteral nutrition)