Mechanism Primary Hypothyroidism Loss of functional thyroid tissue Functional defects in thyroid hormone synthesis and release Secondary Hypothyroidism Loss of functional hypothalamic or pituitary tissue Functional defects in TSH synthesis and release Peripheral...
Inhibition of Ionic Trapping Inhibition of Hormone Synthesis Inhibition of Hormone Release Prevention of Peripheral Conversion to Thyroid Hormone Destruction of Thyroid Tissue Examples ThiocyanatePerchlorate Thionamides:PropylthiouracilCarbimazoleMethimazole...
β-blockers (Propranolol, Esmolol) Diltiazem Corticosteroids Standard of acute care - most of the immediately life-threatening consequences of thyroid storm are cardiovascularEffective in controlling heart rate; with a slower rate the cardiac failure may actually...