What are the key clinical differences between clonidine and dexmedetomidine? Which features make dexmedetomidine a potentially more useful drug in critically unwell patients? Clonidine Dexmedetomidine Route of Administration Administered orally, transdermally, or intravenously Administered via intravenous infusion only Pharmacokinetics Onset of action 10 minutes IVTerminal half-life ~7 hours20% bound to plasma proteins Volume distribution...