SOE 525: Antibiotics

IntroductionYou are anaesthetising a 64-year-old lady for an elective total knee replacement. The surgeons ask you to give prophylactic teicoplanin and gentamicin prior to skin...

What are the benefits and risks of antibiotic prophylaxis?

Benefits Reduction in surgical-site infectionsReduction in infection following high risk exposure Risks Societal RisksSelection of resistant microorganisms and the induction of antibiotic resistance Individual RisksAntibiotic allergy and toxicityRisk of superinfection...

What are the principles of antibiotic prophylaxis?

Surgical Prophylaxis (NICE Guidelines)Clean surgery involving the placement of a prosthesis or implantClean-contaminated surgeryContaminated surgerySurgery on a dirty or infected woundDental surgery in specific sub-groups of patients at risk for infective endocarditis...

What are the indications for antibiotic prophylaxis?

Surgical Prophylaxis (NICE Guidelines)Clean surgery involving the placement of a prosthesis or implantClean-contaminated surgeryContaminated surgerySurgery on a dirty or infected woundDental surgery in specific sub-groups of patients at risk for infective endocarditis...

What is an antibiotic?

An antibiotic is chemical substance that can inhibit the growth of or destroy bacteria without damaging the host cell at therapeutic levels Traditionally the term referred to substances produced by a living organism but today it is used more broadly to include any...