Mechanisms remain unclear but thought to be due to: Reduced patient-ventilator dyssynchrony Improved chest wall compliance resulting in reduced driving pressures Anti-inflammatory effect Not established whether these are limited to (cis-) atracurium or wider NMB...
RCT: ACURASYSPapazian et al NEJM (2010)View Paper RCT: ROSEARDSNet NEJM (2019)View Paper Intervention Cisatracurium vs. placebo for 48 hours Cisatracurium vs. placebo for 48 hours Population 348 patients with severe ARDS (P/F ratio <13 kPa) 1006 patients with...
