A method of ventilation which has become the routine in all ICU patients The core principles of lung-protective ventilation are: Low Tidal Volumes (Vt) Low Driving Pressure Use of PEEP Permissive Hypercapnia Avoidance of Hyperoxia 5-7ml/kg ideal body weight...
Improved V/Q matching (probably most important factor) More uniform distribution of ventilation and perfusion Prevents atelectatic bases receiving highest blood flow A relative increase in functional residual capacity Reduction of cephalad pressure on the diaphragm...
RCT: PROSEVAGuerin et alNEJM (2013)View Paper Meta-AnalysisMunshi et alAnnals of ATS (2017)View Paper Intervention Prone ventilation for 16 hours per day for up to 5 days Prone vs. supine position in mechanical ventilation Population 474 patients with moderate to...
