Given the very low incidence of TTP suggested that TTP managed at a regional referral centre: Have multidisciplinary teams with experience in ICU and long- term aspects of management National agreement now in place with Regional Ambulance Services that TTP forms one...
Should be initiated as soon as possible (preferably within 4-8 hours of diagnosis): Early initiation associated with better outcomes May require emergency transfer to specialist centre Should not wait for result of ADAMTSq3 activity assay Ideally daily spun apheresis...
