Introduction A 24 year-old man, presents to the emergency department with a widespread erythematous rash covering his trunk and face. He has recently been diagnosed with epilepsy and started on lamotrigine. The admitting team are concerned that this could be Stevens...
SJS and TEN are severe muco-cutaneous reactions characterized by erythema, extensive epidermal necrosis, and widespread bullous epidermal detachment. They are most commonly triggered by drugs and affect all age groups Widespread skin loss from these conditions leads...
Characterized histologically by keratinocyte apoptosis and separation of the epidermis from the dermis at the dermo-epidermal junction (black arrows) Leads to extensive epidermal destruction Proposed mediators are: Cytokines including fas-fas ligand and tumour...
