Classical receptor theory suggests that the response seen will be proportional to the percentage of receptors occupied In this situation when the relationship between receptor occupancy and response is linear Occupancy is directly proportional to efficacy Affinity is...
TD50(Median Toxic Dose) LD50(Median Lethal Dose) The concentration of a drug that produces a specific response that is exactly halfway between baseline and maximum The dose of a drug that induces a specific response in exactly 50% of the population who take it Related...
The therapeutic index is the ratio of the dose that produced toxicity to the dose that produces a clinically desired effect: It is a statement of the relative safety of a drug – the larger the TI, the safer the drug In animal models, the LD50 may be used instead...
