Term Efficacy(Intrinsic Activity) Definition) A measure of the magnitude of the effect that a drug-receptor system produces Description Can be described using graded or quantal responsesGraded responseValue between 0 - 100% given depending on the effect on a...
Can be measured by assessing graded or quantum response: Graded Response Quantal response Measures the efficacy of a receptor-effector in a particular system (e.g. tissue, animal or patient)Measures effect on a continuous scaleUsed to plot drug concentration vs....
Term Potency Definition A measure of the quantity of drug needed to produce maximal effect Description Drugs of high potency produce an effect bind at low concentration compared with drugs of low potency which require a high concentration to bind to a critical number...
Graded ResponseEC50(Median Effective Concentration) Quantal ResponseED50(Median Effective Dose) The concentration of a drug that produces a specific response that is exactly halfway between baseline and maximum The dose of a drug that induces a specific response in...
Potency of a drug is described by it’s ED50 or EC50 depending upon the use of graded or quantal responseEC50 / ED50 are best represented using a dose-response curve (efficacy vs...
