The unique anatomical and physiological properties of the central nervous system microvasculature that allows it to tightly regulate the movement of molecules, ions, and cells between the blood and the CNS Related Pages: (5.6)...
Comprises of 3 cellular layers and a basement membrane Together these form a barrier virtually impenetrable barrier to lipophobic molecules Capillary Endothelium Basement Memebrane Pericytes Astrocytes Interconnected by tight junctions (50-100x 'tighter' than...
Continuous Non-Fenestrated (General) Muscle, thymus, bone, lung Continuous endothelial cytoplasm without fenestrae and continuous basement membrane which restricts passage of substances across the endotheliumTight junctions between cells limiting paracellular movement...
Certain areas of the brain have a reduced blood-brain barrier and retain a direct connection with the systemic circulation in order to Detect alterations in composition of the blood Allow secretion of hormones Areas that are outside the BBB are known as...
